Effexor (venlafaxine) was the first antidepressant in the class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). It is available in an extended-release formula to treat depression, and anxiety and panic disorders. In our latest question and answer, the pharmacist discusses whether or not Mucinex DM is safe to use during pregnancy. Important Information. Do not use Effexor XR within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. What other drugs will affect Effexor? Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Effexor with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Although pregnancy has typically been considered a time of emotional well-being, recent studies suggest that up to 20% of women suffer from mood or anxiety disorders during pregnancy. I’m in my first trimester and I’m struggling with depression bad right now. I feel nauseous all day and miserable. Hoping that it gets better soon. Venlafaxine is used to treat depression, anxiety, panic attacks, and social anxiety disorder (social phobia). It may improve your mood and energy level and may help restore your interest in daily living. Find patient medical information for Effexor XR Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Effexor (venlafaxine) is an antidepressant used for treatment of major depression. A generic version of Effexor is available. Side effects of Effexor include Drugs in Pregnancy - Explore from the Merck Manuals - Medical Professional Version.